“Exploring the Hidden World of MiruViruses: The Smallest Known Viruses”

Neha Pal , PhD Microbiology
3 min readMay 3, 2023

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Mirusviruses are a newly discovered group of viruses that belong to the family Phycodnaviridae. These viruses have a unique structure and genome organization that distinguishes them from other members of the family. Mirusviruses were first discovered in 2019, and since then, they have been identified in various environments, including marine and freshwater ecosystems. This article will provide an overview of mirusviruses, their structure, replication cycle, and potential impact on their host organisms.

Discovery of Mirusviruses:
The first mirusvirus was discovered in a freshwater lake in the United States in 2019. Subsequently, several other mirusvirus strains were found in different environments, including freshwater and marine ecosystems. The discovery of mirusviruses has expanded our understanding of the diversity of viruses in the environment.

Structure of Mirusviruses:
Mirusviruses have a complex structure consisting of a core shell, an inner membrane, and an outer membrane. The core shell contains the viral DNA, which is circular and double-stranded. The inner membrane separates the core from the outer membrane, and it is thought to be involved in the packaging and release of viral particles. The outer membrane is studded with viral proteins that facilitate attachment to the host cell.

Replication Cycle of Mirusviruses:
The replication cycle of mirusviruses is not well understood, but it is thought to be similar to other members of the family Phycodnaviridae. Mirusviruses infect host cells by attaching to specific receptors on the cell surface. Once inside the host cell, the virus releases its genetic material, which takes over the host’s cellular machinery to produce new viral particles. The new virus particles are assembled, and they are released from the host cell, usually causing cell lysis.

Impact of Mirusviruses on Host Organisms:
The impact of mirusviruses on their host organisms is not well understood. However, it is thought that they may play a role in the regulation of algal populations in marine and freshwater ecosystems. Some mirusviruses have been found to infect specific strains of algae, suggesting that they may play a role in shaping algal communities. Additionally, mirusviruses have been found to contain genes that encode for enzymes involved in nutrient cycling, suggesting that they may be involved in the cycling of nutrients in the environment.

Conclusion:
Mirusviruses are a newly discovered group of viruses that have a unique structure and genome organization. While their impact on their host organisms is not well understood, they may play a role in the regulation of algal populations and nutrient cycling in the environment. The discovery of mirusviruses has expanded our understanding of the diversity of viruses in the environment and highlights the need for further research to elucidate their role in ecosystem functioning.

References:

Dunigan DD, Kondov NO, Gurnon JR, et al. Phycodnaviruses: a peek at genetic diversity. Virus Res. 2006;117(1):119–132.
Deeg CM, Chow C-ET, Suttle CA. The kinetoplast-like DNA of the giant mimivirus encodes for an essential dinucleotide primase. Proc Natl Acad Sci U S A. 2018;115(11):E2566-E2573.
Luque D, Rivas G, Alfonso C, Carrascosa JL. Phycodnaviridae: a peek at the diversity and evolution of large DNA viruses infecting eukaryotic algae. Crit Rev Plant Sci. 2013;32(4):465–509.
Fischer MG, Suttle CA. A virophage at the origin of large DNA

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Neha Pal , PhD Microbiology
Neha Pal , PhD Microbiology

Written by Neha Pal , PhD Microbiology

Postdoctoral researcher , passionate exploring phototherapy treatments, curious the truth of uncovering world

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